Publications

2020

Duman M, Vaquié A,Nocera G, Heller M, Stumpe M, Siva Sankar D, Dengjel J, Meijer D, Yamaguchi T, Matthias P, Zeis T, Schaeren-Wiemers N, Hayoz A, Ruff S, Jacob C (2020). EEF1A1 deacetylation enables transcriptional activation of remyelination. Nature Communications 11: 3420. Link

Nocera G, Jacob C (2020). Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury. Cellular and Molecular Life Sciences 77: 3977–3989. Link

Duman M,  Martinez-Moreno M, Jacob C, Tapinos N (2020). Functions of histone modifications and histone modifiers in Schwann cells. Glia, Special Issue on Epigenetics, 68: 1584–1595. Link

2019

Vaquié A, Sauvain A, Duman M, Nocera G, Egger B, Meyenhofer F, Falquet L, Bartesaghi L, Chrast R, Lamy CM, Bang S, Lee S-R, Jeon NL, Ruff S, Jacob C (2019). Injured axons instruct Schwann cells to build constricting actin spheres to accelerate axonal disintegration. Cell Reports 27: 3152–3166. Cover Link

2018

Vaquié A, Sauvain A, Jacob C (2018). Modeling PNS and CNS myelination using microfluidic chambers, in Myelin: Methods and Protocols, Springer Protocols. Methods in Molecular Biology 1791: 157–168. Link

2017

Jacob C (2017). Chromatin-remodeling enzymes in control of Schwann cell development, maintenance and plasticity. Current Opinion in Neurobiology 47: 24–30. Link

Jacob C (2017). Accélérer la repousse axonale en retardant la réponse des histone déacétylases après une lésion nerveuse. HAUSARZT PRAXIS medizinonline 12(4): 8–9. Link

Brügger V, Duman M, Bochud M, Münger E, Heller M, Ruff S, Jacob C (2017). Delaying histone deacetylase early response to injury accelerates conversion into repair Schwann cells and nerve regeneration. Nature Communications 8: 14272. F1000 Link

2016

Mishra S, Khaddaj R, Cottier S, Stradalova V, Jacob C & Schneiter R (2016). Mature lipid droplets are accessible to ER luminal proteins. Journal of Cell Science 129: 3803–3815.

2015

Brügger V, Engler S, Pereira JA, Ruff S, Horn M, Welzl H, Münger E, Vaquié A, Sidiropoulos PNM, Egger B, Yotovski P, Filgueira L, Somandin C, Lühmann TC, D’Antonio M, Yamaguchi T, Matthias P, Suter U & Jacob C (2015). HDAC1/2-dependent P0 expression maintains paranodal and nodal integrity independently of myelin stability through interactions with neurofascins. PLOS Biology 13(9): e1002258. Featured in Synopsis of PLoS Biology 13:e1002259 Link

Jacob C (2015). Transcriptional control of neural crest specification into peripheral glia. Glia 63: 1883–1896. Link

2014

Jacob C, Lötscher P, Engler S, Baggiolini A, Varum Tavares S, Brügger V, John N, Büchmann-Møller S, Snider PL, Conway SJ, Yamaguchi T, Matthias P, Sommer L, Mantei N & Suter U (2014). HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia. Journal of Neuroscience 34(17): 6112–6122. Link

2013

Jacob C (2013). Mechanisms that control Schwann cell plasticity after a PNS lesion. e-News for Somatosensory Rehabilitation.10(2): 59–62. Link

Pattaroni C & Jacob C (2013) Histone methylation in the nervous system: functions and dysfunctions. Molecular Neurobiology 47: 740–756. Link

2011

Jacob C, Lebrun-Julien F & Suter U (2011). How histone deacetylases control myelination. Molecular Neurobiology 44: 303–312. Link

Jacob C, Christen CN, Pereira J, Somandin C, Baggiolini A, Lötscher P, Özçelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P & Suter U (2011). Schwann cell survival and myelination are critically dependent on HDAC1 and HDAC2 function. Nature Neuroscience 14: 429-436. Featured in News and Views of Nature Neuroscience 14: 401–403. F1000 Link

2010

Cotter L, Özçelik M, Jacob C, Pereira JA, Locher V, Baumann R, Relvas JB, Suter U & Tricaud N (2010). Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science 328: 1415–1418. F1000 Link

Pereira JA, Baumann R, Norrmén C, Somandin C, Miehe M, Jacob C, Lühmann T, Hall-Bozic H, Mantei N, Meijer D & Suter U (2010). Dicer in Schwann cells is required for myelination and axonal integrity. Journal of Neuroscience 30: 6763–6775. Link

Ozçelik M, Cotter L, Jacob C, Pereira J, Relvas J, Suter U & Tricaud N (2010). Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. Journal of Neuroscience 30: 4120–4131. Link

2008

Jacob C, Grabner H, Atanasoski S & Suter U (2008). Expression and localization of Ski determine cell type-specific effects of TGFbeta on the cell cycle. Journal of Cell Biology 182: 519–530. Link

2006

Jacob C & Bunnett N (2006). Transmembrane signaling by G protein-coupled receptors. Chapter 3 In "Physiology of the gastrointestinal tract" 4th Edition (LR Johson), Vol 1, pp 63–90 Academic Press.

2005

Jacob C, Yang P, Darmoul D, Amadesi S, Cotrell GS, Saito T, Singh P, Grady E F, Perdue M & Bunnett NW (2005) Mast cells control paracellular permeability of the intestine: role of protease-activated receptor 2 and beta-arrestins. Journal of Biological Chemistry 280: 31936–31948.

Jacob C, Cotrell GS, Schmidlin F, Grady EF & Bunnett NW (2005). The E3-ubiquitin ligase c-Cbl regulates protease-activated receptor 2 (PAR2). Journal of Biological Chemistry 280: 16076-16087.

2004

Jacob C, Szilagyi C, Allen JM, Bertrand C & Lagente V (2004). Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism. British Journal of Pharmacology 143: 257–268.

Martin-Chouly C, Astier A, Jacob C, Pruniaux M-P, Bertrand C & Lagente V (2004). Modulation of MMP-2 production from human lung fibroblasts by selective phosphodiesterase type-4 inhibitors. Life Sciences 75: 823–840.

2002

Jacob C, Leport M, Szilagyi C, Allen JM, Bertrand C & Lagente V (2002). DMSO-treated HL60 cells: a model of neutrophil-like cells mainly expressing PDE4B subtype. International Immunopharmacology 2: 1647–1656.

Jacob C, Martin-Chouly C & Lagente V (2002). Type 4 phosphodiesterases dependent pathways: Role in inflammatory processes. Therapie 57: 163–168.