21 June 2023, We were very happy to welcome at the Biozentrum I Alexander Steinhoff from the Mainzer Wissenschaftsstiftung, who supported our clinical trial project for the repair of lesions in multiple sclerosis patients! It was great to meet and discuss our project in more details and learn about the goals of the Foundation. Article in Fördern & Stiften JGU Mainz October 2023
October 2023, Our most advanced work to repair lesions in Multiple Sclerosis patients and other demyelinating conditions got featured in the FAZ! Article Theophylline patch in FAZ
Wie Nerven zu neuem Leben erweckt werden
June 2023, Katharina started her Master in our lab.
Welcome, Katharina!
13 June 2023. Gianluigi defended his PhD.
Congratulations, Gianluigi!
14 October 2022. Himanshu joined our lab as a Postdoc to work on a collaborative project with the group of Martin Heine (also at the IDN), and the groups of Andreas Walther and Pol Besenius (both in the Dept of Chemistry).
Welcome, Himanshu!
1 September 2021. Gunnar joined our lab to do his Master with us through the ERASMUS program. Welcome, Gunnar!
10 August 2021. Xinda joined our lab as internship student and will soon start his PhD with us. Welcome, Xinda!
19 August 2020. Mert's Farewell Party. After a very productive PhD and short Postdoc with us, first in Fribourg (Switzerland) and then here in Mainz, Mert went on to the University of Bern in Switzerland to continue his career as a Postdoc in Neuroscience. We all wish Mert the best of luck and a lot of success for his new career step!
9 July 2020. Congratulations to Mert, the first author, and to all co-authors of our new publication in Nature Communications! In this article, we elucidate a major mechanism that controls myelination and remyelination after lesion and we identify a treatment that promotes remyelination in the peripheral and central nervous systems after traumatic or demyelinating lesions.
Duman M, Vaquié A,Nocera G, Heller M, Stumpe M, Siva Sankar D, Dengjel J, Meijer D, Yamaguchi T, Matthias P, Zeis T, Schaeren-Wiemers N, Hayoz A, Ruff S, Jacob C (2020). EEF1A1 deacetylation enables transcriptional activation of remyelination. Nature Communications 11: 3420. Link to publication
Link to Podcast with Nele Handwerker: in English, in German
15 July 2019. Our first Summer Party at BZ1!
Nothing wrong with solid planning... Video
11 June 2019. Our first publication in Mainz and our first cover! Congratulations to Adrien, the first author, and to all co-authors of this article published in Cell Reports! This study identifies a novel aspect of Schwann cell plasticity required for timely clearing of damaged axons and axonal regrowth after lesion and its triggering mechanism, which depends on VEGFR1. In addition, we show that this behavior can be transferred into mature oligodendrocytes after axonal lesion in our microfluidic models.
Vaquié A, Sauvain A, Duman M, Nocera G, Egger B, Meyenhofer F, Falquet L, Bartesaghi L, Chrast R, Lamy CM, Bang S, Lee S-R, Jeon NL, Ruff S, Jacob C (2019). Injured axons instruct Schwann cells to build constricting actin spheres to accelerate axonal disintegration. Cell Reports 27: 3152–3166. Link to publication, Link to press release
27 September 2018. Prof. Jacob receives the IRP Schellenberg Research Prize together with Prof. Götz
Photo (c) Urs Albrecht, Fribourg (CH). From left to right: Prof. Andreas J. Steck, Philippe Boissonnas, Prof. Magdalena Götz, Prof. Claire Jacob, Prof. Theodor Landis